Sweetness Synergy in Binary and Ternary Sweetener Combinations | Jul-2026
- Yuval Klein
- 2 days ago
- 1 min read

We are pleased to share MAMAY's latest peer-reviewed study, “Sweetness Synergy in Binary and Ternary Sweetener Combinations: A Systematic Literature-Derived Database and Mechanistic Interpretation.
This research establishes a quantitative framework for understanding how sweeteners interact at the receptor level to produce supra-additive sweetness effects. The findings highlight the mechanistic role of compounds such as NHDC, Aspartame, and Stevia Rebaudioside A in cooperative activation of the TAS1R2/TAS1R3 receptor complex.
The resulting database and mechanistic insights form the scientific foundation of MAMAY Digitizer, MAMAY's data-driven platform for predictive formulation design and optimization.




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